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AHCC (Active Hexose Correlated Compound) is a patented, clinically researched extract derived from cultured shiitake mushroom mycelia. Developed in Japan through collaboration between Amino Up Co., Ltd. and the University of Tokyo, AHCC is produced using a proprietary cultivation and enzymatic process that concentrates its unique bioactive compounds.
AHCC contains a distinctive profile of partially acylated alpha-glucans, which are not found in typical mushroom powders or extracts. These alpha-glucans are believed to play a key role in AHCC’s immune-modulating properties and are the primary factor that differentiates AHCC from other mushroom-based supplements.

Mushroom-Derived Immune Support with AHCC®
AHCC® is a patented, clinically researched extract derived from shiitake mushroom mycelia that supports balanced immune function. I use it during periods of high stress, before travel or when there is a flu outbreak as part of an immune support protocol.
Laura JohnsonCEO at Phytoceutics® & Nutritional Health Coach
Benefits of AHCC
While AHCC offers multiple health benefits, its primary and most well-documented effect is immune modulation, supported by scientific and clinical research. AHCC has been used for over two decades in clinical settings worldwide and is valued for its role in supporting balanced immune function, which is important for immune defence, inflammatory control, and normal cellular health.
01. AHCC® and the immune system
Through its influence on the immune system, AHCC® may help preserve immunity in those whose defense system is slowly being infiltrated by viruses. Preliminary trials with AHCC® have given encouraging results in certain viral infections.
Infections are caused by the invasion and the multiplication of microorganisms in the body. We carry 500 to 1000 different species of bacteria throughout our body. Adequate immunity is therefore crucial in preventing infection. Several experiments confirmed AHCC®’s competence to support healthy immune function.
How does AHCC work?
Mushrooms and mushroom-derived supplements have a long history of use in healthcare. Although AHCC® is derived from shiitake mushrooms, it is not a simple mushroom powder or extract. AHCC® is a cultured mycelial extract produced using a specialised and controlled process that results in a consistent, standardised composition in every batch. A key point of differentiation is its unique glucan profile. Unlike most mushroom supplements, which are primarily rich in beta-glucans, AHCC® contains a high concentration of alpha-glucans, with an approximate alpha- to beta-glucan ratio of 30:1.
AHCC® contains bioactive compounds that act as non-toxic agonists of Toll-like receptors (TLR-2 and TLR-4), which play a role in innate and adaptive immune responses. These receptors are involved in immune signalling, and AHCC® supports healthy immune modulation through appropriate activation pathways.